Like with any other major city in the States there are some neighborhoods that are better (or worse) than others. What different about SF is its geographical limitations. Located on a peninsula, there is no room for new money to expand letting ghettos fill the void of the businesses or residents that would have relocated. In SF you can walk for 6 block and hit two “high rent” hoods and two ghettos. (a little exaggeration but you get the idea)
The neighborhoods that have a worse reputation are The Tenderloin, The Mission and SOMA. (I would rank them in this order as well – from bad to not as bad) There are a few others, but these 3 areas do have nightclubs and bars that attract the nightlife. The only precautions would be 1) be aware where you park if you have a car and 2) don’t walk around these places at night SOLO. The safest bet is to take a taxi from where you are staying to your destination, and you will have no probblem.
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