The Rough Guide had Cafe Sybille listed as one of the top places to go while in Berlin, I'm not quite sure why. I stopped in while on my way to explore Friedrichshain, and I felt as if I was in a suburban starbucks. It seemd very weird, almost as if they were closed, and the menu wasn't that great so I had a tea and found a much more happening place to eat lunch in Friedrichshain. I must say, the staff was friendly, but that didn't make up for the altogether strange vibe. A whole half of the place didn't even have the lights turned on and I think I was the only customer inside.
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At Least Do This: Use the restroom and keep on walking down Karl Marx Alle.
Alternative: Walk a few more blocks and turn off to the interesting and hip side streets of Friedrichshain. There you will find great cafes, restaurants, bars and shops.